Figure 4 | Laboratory Investigation

Figure 4

From: Human Hepatocellular Carcinoma (HCC) Cells Require Both α3β1 Integrin and Matrix Metalloproteinases Activity for Migration and Invasion

Figure 4

Integrin expression on HCC cellular surface. All of the HCC cells studied express α2, β1, α6, and β4 integrin subunits. Chang, HLE, HLF, and SK-Hep1 also express high levels of the α3 subunit, whereas Hep3B, HepG2, and HepG2.2.15 are completely negative and Alexander show only weak immunoreactivity. As a negative control, monoclonal antibodies directed against thyroglobulin (Tγ) or against aIIbβ3 (CP3) were used, followed by the secondary antibody. Immunohistochemistry was performed using at least two distinct monoclonal antibodies directed against each integrin subunit.

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