Figure 6 | Laboratory Investigation

Figure 6

From: Human Hepatocellular Carcinoma (HCC) Cells Require Both α3β1 Integrin and Matrix Metalloproteinases Activity for Migration and Invasion

Figure 6

HCC cells adhere on Ln-5 via α3β1 integrin. Chang, HLE, HLF, and SK-Hep1 were plated on Ln-5 coated wells in the presence of anti-integrin functional antibodies. After incubation, adhesion on Ln-5 is inhibited by blocking antibodies directed against α3 (P1B5) and β1 (P4C10), but not by blocking antibodies directed against α2 (P1E6) and α6 (GoH3). No antibodies were added in control (CTRL) wells. Cell adhesion was quantified as described in Figure 5.

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