Figure 3 | Laboratory Investigation

Figure 3

From: Immunohistochemical Detection of Skin-Homing T Cells Expressing Fucosyltransferase VII (Fuc-TVII) In Vitro and In Situ

Figure 3

Double immunohistochemical detection of Fuc-TVII and CLA on infiltrating T cells in biopsy specimens obtained from lichen planus lesions (original magnification, × 132). A, Scattered T cells, seen at the dermal (D)-epidermal (E) junction, coexpress surface CLA (blue) and cytoplasmic Fuc-TVII (red) (arrowheads). Some CLA+ cells that do not express Fuc-TVII are also seen. B, Most of infiltrating T cells around blood vessels (V) in the dermis coexpress CLA (blue) and cytoplasmic Fuc-TVII (red), in either a punctate (arrowhead) or a dotlike (arrows) pattern. The percentages of CLA+ T cells that also coexpressed Fuc-TVII were variable, ranging from 30% to 50%. CLA- Fuc-TVII+ cells were hardly detectable in the skin-infiltrating T cells in situ.

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