Figure 3
From: Mapping and Genome Sequence Analysis of Chromosome 5 Regions Involved in Bladder Cancer Progression
Summary of physical map analysis spanning the deleted regions of chromosome 5 performed as described in “Material and Methods.” Original markers and substitutes for markers with LOH based on the closest proximity were placed on the Genethon map and were repositioned on the GB4 radiation hybrid panel-based physical map. The new positions for the Genethon markers with LOH, as well as flanking markers on the GB4 map, were identified by electronic PCR search of bacterial artificial chromosome (BAC) contigs. In addition, multiple alternative markers based on their proximity to markers with LOH were identified and added to the map. The original Genethon markers with LOH are shown in red. All other substitute and flanking markers are printed in black. In addition, average expressed sequence tag (EST) density for regions flanked by individual markers placed on the GB4 map and a list of 138 known genes mapping to the target regions are shown. To simplify the diagram, contig data used for this analysis are not provided. More complete data with alternative positions of the genes can be obtained from our Web site: http://www.mdanderson.org/bladdergenomicmaps. (cM, centimorgan; cR, centiray)
