Figure 4 | Laboratory Investigation

Figure 4

From: Alpha-1-Antitrypsin and a Broad Spectrum Metalloprotease Inhibitor, RS113456, Have Similar Acute Anti-Inflammatory Effects

Figure 4

Effects of α1AT and RS113456 on nuclear translocation of NF-κB in whole lung. Silica produces a marked increase in NF-κB levels and this is about 50% suppressed by both antiproteases at 2 hours. At 24 hours, some protection is still present with α1AT treatment. Lane 1, control; Lane 2, silica alone; Lane 3, silica + α1AT; Lane 4, silica + RS113456.

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