Figure 9 | Laboratory Investigation

Figure 9

From: Alpha-1-Antitrypsin and a Broad Spectrum Metalloprotease Inhibitor, RS113456, Have Similar Acute Anti-Inflammatory Effects

Figure 9

Effects of α1AT and RS113456 in macrophage metalloelastase (MME) −/− mice. Silica induces a lavage neutrophilia in these mice, and both antiproteases nearly completely block the influx. However, lavage desmosine and hydroxyproline are never elevated in these animals. These findings suggest that the PMN influx after silica exposure is not mediated through generation of chemoattractant matrix fragments and that classic antiproteolysis (complexing of the protease and antiprotease) is not playing a role in the suppressive effects of antiproteases. Values are mean ± sd. * Significantly greater than control.

Back to article page