Figure 10 | Laboratory Investigation

Figure 10

From: Articular Chondrocytes from Animals with a Dermatan Sulfate Storage Disease Undergo a High Rate of Apoptosis and Release Nitric Oxide and Inflammatory Cytokines: A Possible Mechanism Underlying Degenerative Joint Disease in the Mucopolysaccharidoses

Figure 10

Possible mechanism underlying degenerative joint disease in MPS VI. As MPS VI articular chondrocytes age, they accumulate and release excess amounts of dermatan sulfate-containing glycosaminoglycans. These cells eventually undergo apoptosis, caused by either the accumulating dermatan sulfate itself or cytokine-induced NO production resulting from mechanical stress on the MPS joints. The resulting MPS articular cartilage has an abnormal matrix composition that eventually causes functional deficits of the articular surfaces.

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