Figure 3 | Laboratory Investigation

Figure 3

From: Frequent Allelic Imbalance and Loss of Protein Expression of the DNA Repair Gene hOGG1 in Head and Neck Squamous Cell Carcinoma

Figure 3

Loss of heterozygosity (LOH) analysis of normal and neoplastic squamous epithelium using exon 7 SNP. These nine microdissected tissue samples were obtained from a subject (Case 4 in Table 1) manifesting human 8-oxoguanine DNA glycosylase 1 (hOGG1) allelic loss in the tumor. Samples 1, 2, 3, 6, 7, and 8 were obtained from histologically benign but hyperplastic squamous mucosa. These samples show no evidence of allelic loss. Samples 4 and 9 are from the tumor and confirm allelic imbalance. Sample 5 is taken from normal-appearing minor salivary gland and serves as an internal negative control.

Back to article page