Table 1 hOGG1 Allelic Imbalance and IHC Staining: Results of 18 Informative HNSCC Cases

From: Frequent Allelic Imbalance and Loss of Protein Expression of the DNA Repair Gene hOGG1 in Head and Neck Squamous Cell Carcinoma

Case

Diagnosis

Location

Clinical stage

Informative Ex7/In4

+LOH

IHC Staining

1

SCC

Tongue

IV

Yes/Yes

Yes

NA

2

SCC

Tongue

IV

Yes/Yes

Yes

NA

3

SCIS

Buccal

0

No/Yes

Yes

NA

4

SCC

Tongue

IV

Yes/Yes

Yes

5

VSCC

Alveolar

II

Yes/Yes

Yes

++

6

SCC

Tongue

III

Yes/Yes

Yes

+++

7

SCC

Tongue

IV

Yes/Yes

No

+++

8

SCC

Buccal

II

Yes/No

No

++++

9

SCC

Tongue

III

Yes/Yes

No

++

10

SCC

Tongue

III

Yes/Yes

No

++++

11

SCC

Tongue

III

Yes/Yes

No

+++

12

BSCC

Larynx

III

Yes/Yes

Yes

13

BSCC

Larynx

IV

No/Yes

No

++++

14

BSCC

Larynx

IV

Yes/Yes

Yes

15

BSCC

Tongue

IV

Yes/Yes

Yes

−/+

16

BSCC

Larynx

IV

Yes/No

Yes

+++

17

BSCC

Tongue

IV

Yes/Yes

No

+++

18

BSCC

Larynx

IV

Yes/Yes

Yes

−/+

  1. hOGG1, human 8-oxoguanine DNA glycosylase; HNSCC, head and neck squamous cell carcinoma; SCC, conventional squamous cell carcinoma; SCIS, squamous cell carcinoma in situ; VSCC, verrucous squamous cell carcinoma; BSCC, basaloid squamous cell carcinoma; Ex7, exon 7; In4, intron 4; LOH, loss of heterozygosity; IHC, immunohistochemical; NA, not available.