Table 2 Number of NEBs per Section and Average Number of Cells per NEB in Control and Silica-Treated Rats Killed at Different Timesa

From: Hyperplasia of Alveolar Neuroendocrine Cells in Rat Lung Carcinogenesis by Silica with Selective Expression of Proadrenomedullin-Derived Peptides and Amidating Enzymes

Time

Alveolar

Bronchiolar

 

NEB/cm2

Cells/NEB

NEB/cm2

Cells/NEB

Fetal rat

  

29.131 ± 2.37

5.25 ± 0.42

Aged ratsb

3.68 ± 2.28

6.37 ± 4.08

6.21 ± 3.32

6.69 ± 2.87

Saline instilledc

2.13 ± 2.84

2.44 ± 2.36

3.01 ± 3.25

2.44 ± 2.69

Controld

4.05 ± 4.32

2.59 ± 2.36

2.61 ± 2.47

1.96 ± 1.31

1 mo

3.97 ± 1.98

8.1 ± 2.78

4.81 ± 2.24

8.7 ± 3.69

2 mo

1.72 ± 1.79

3.51 ± 3.25

1.16 ± 0.76

4.42 ± 4.24

3 mo

1.13 ± 0.15

2.5 ± 0.36

3.38 ± 0.12

3.66 ± 0.14

4 mo

1.95 ± 1.3

5.27 ± 3.55

1.54 ± 0.75

6.05 ± 1.3

5 mo

1.95 ± 0.22

5.71 ± 1.53

2.91 ± 0.23

5.16 ± 2.11

11 mo

11.7 ± 0.47

9.84 ± 2.61

4.7 ± 1.37

3.47 ± 0.81

17 mo

13.9 ± 4.92*

34.6 ± 9.17*

1.95 ± 1.12

9.64 ± 6.33

23 mo

23.9 ± 6.76*

32.8 ± 7.60*

4.21 ± 0.60

8.25 ± 1.37

  1. Both the number of alveolar NEBs per section and the average number of cells per alveolar NEB, increase significantly with time. Based on CGRP immunostaining.
  2. bAged rats, untreated rats, ages 19 to 28 months (n = 34).
  3. cSaline instilled, 8-week-old rats instilled with saline only and killed at different time points: 1 month (n = 2), 2 months (n = 10), 4 months (n = 2), 6 months (n = 4).
  4. dControl, untreated 8-week-old rats (n = 15).
  5. *p < 0.01. p values were calculated using a Kruskal Wallis test and U-Mann Whitney as post hoc test, comparing each time point with time 0. Bonferroni adjustment was applied.
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