Figure 2
From: Podocyte Injury Promotes Progressive Nephropathy in Zucker Diabetic Fatty Rats
High-resolution microscopic features of the glomerular profile in ZDF-fa/fa rats. A, Glomeruli from 5-month-old lean rats showing neither apparent glomerular enlargement nor mesangial expansion. B, Glomerulus at 5 months in a ZDF-fa/fa rat showing some hypertrophy of glomerular tuft with segmental mesangial accentuation (arrow) and scattered cytoplasmic deposition in podocytes (arrowheads). C, Glomerulus from a 7-month-old ZDF-fa/fa rat. Mild mesangial thickening with synechiae can be seen. Note conspicuous droplets and vacuolation in podocytes. No nodular lesions were seen. D, Glomerulus from a ZDF-fa/fa rat at 7 months. Note segmental sclerosis with capillary collapse near the vascular pole. Original magnification, A–D, ×400.
