Table 1 Pathophysiological Data of ZDF-fa/fa and Lean Rats

From: Podocyte Injury Promotes Progressive Nephropathy in Zucker Diabetic Fatty Rats

  

Body weight g

Kidney weight g

Blood glucose mg/dl

Plasma insulin ng/ml

MAP mmHg

GFR ml/min

Proteinuria mg/day

3 mo

Lean

256 ± 18

2.17 ± 0.11

123 ± 6

1.16 ± 0.17

111 ± 2

0.37 ± 0.10

7.3 ± 2.1

 

fa/fa

337 ± 19**

3.32 ± 0.11**

337 ± 58*

6.47 ± 1.88*

125 ± 9

0.72 ± 0.08*

30.6 ± 12.5

5 mo

Lean

424 ± 11

2.58 ± 0.04

140 ± 5

2.42 ± 0.45

130 ± 9

2.30 ± 0.18

7.2 ± 1.6

 

fa/fa

440 ± 8

3.58 ± 0.15**

512 ± 62**

1.87 ± 0.26

118 ± 7

3.80 ± 0.57*

68.7 ± 15.3**

7 mo

Lean

461 ± 8

2.60 ± 0.11

134 ± 3

2.45 ± 0.28

123 ± 4

1.90 ± 0.20

32.8 ± 10.0

 

fa/fa

425 ± 10*

4.10 ± 0.15**

576 ± 57**

1.25 ± 0.16**

131 ± 7

1.80 ± 0.12

258.3 ± 114.9**

9 mo

Lean

480 ± 5

2.62 ± 0.15

196 ± 22

3.77 ± 0.51

126 ± 4

1.75 ± 0.50

14.0 ± 3.2

 

fa/fa

412 ± 9**

4.23 ± 0.20**

567 ± 28**

0.99 ± 0.17**

140 ± 8

1.85 ± 0.25

286.0 ± 59.0**

  1. Values are expressed as means ± SEM; n = 6 rats per group.
  2. MAP, mean arterial pressure; GFR, glomerular filtration rate.
  3. *p < 0.05
  4. **p < 0.01 versus ZDF-lean rats of the same age.