Figure 2
From: Tissue Distribution and Induction of Human Multidrug Resistant Protein 3
Immunohistochemical detection of MRP3 and MDR1 P-gp in adrenal gland (upper panel) and pancreas (lower panel) using aminoethyl carbazole as the chromogen. MRP3 was stained with M3II-9 (a and d) and MDR1 P-gp with C219 monoclonal antibody (Mab) (b and e). Staining with the negative control antibody is shown in c and f. MRP3 is present in the adrenal cortex in the cells of the zona fasciculata and the zona reticularis. MDR1 P-gp is detected in all three layers of the adrenal cortex. In human pancreas, MRP3 staining is observed in the basolateral membranes of the epithelial cells of the ductules. Control stainings for MDR1 P-gp show a more apically oriented staining, in the epithelial cells of smaller, thinner ducts.
