Figure 1
From: Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma
A, Eosinophils within the tracheal epithelium of a sensitized chronically exposed BALB/c mouse at 3 hours following exposure to ovalbumin. B, Immunoperoxidase staining for eotaxin in the airway wall of a sensitized chronically exposed BALB/c mouse at 3 hours following exposure to ovalbumin. Using a concentration of antieotaxin four-fold lower than that required for optimal staining, there is still moderate immunoreactivity of airway epithelial cells and strong staining of the cytoplasm of plasmacytoid inflammatory cells in the lamina propria. C, Same region from a consecutive section, demonstrating virtually complete inhibition of staining by preincubation of the antibody with the corresponding blocking peptide. D, Absence of immunoreactivity for eotaxin in the airway wall of a sensitized chronically exposed BALB/c mouse at 24 hours following exposure to ovalbumin. E, Immunoperoxidase staining for eotaxin in the trachea of a sensitized chronically exposed IL-13 −/− mouse at 3 hours following exposure to ovalbumin, demonstrating strong immunoreactivity of both airway epithelial cells and plasma cells in the lamina propria.
