Figure 2
Graft function (A), antidonor cytotoxic T lymphocyte (CTL) reactivity in cell mediated lympholysis (CML) assay (B), and circulating antidonor major histocompatibility complex (MHC) class I IgG (C) in the progression (• or ▪: n = 4) and recovery (• or □: n = 4) groups. (□) and (□) in (B) represent values of CTL responses against third party type antigen in animals of the progression (□: n = 4) and recovery (□: n = 4) groups. Note that animals of the progression group show long-term graft dysfunction (A), prolonged donor specific CTL reactivity (B), and persistent production of antidonor class I antibody (C). In contrast, animals of the recovery group show a transient elevation in Cr (A), development of donor specific hyporesponsiveness by Day 30 (B), and reduced levels of circulating antidonor class I IgG by Day 60 (C). B and C, Values are expressed as mean ± sd.
