Figure 8
Progression group showing TUNEL (blue) and GS-IB4+ (brown) damaged endothelial cells (A, B), PCNA (blue) and GS-IB4+ (brown) proliferating endothelial cells (C, D), PCNA (blue) and α-actin+ (brown) activated and proliferating mesangial cells (E, F), and incomplete recovery of capillary structure in GS-IB4 staining (G, H) on Day 30 (A, C, E, G) and Day 60 (B, D, F, H). During the development of chronic allograft glomerulopathy, endothelial cell injury, mesangial cell proliferation, and activation is still evident at Day 60. Capillary repair with endothelial cell proliferation occurs after acute allograft glomerulopathy, however, glomerular capillary structure shows incomplete recovery at Day 60. A to F, ×800; G, H, ×700.
