Figure 2
From: Chymase Participates in Chronic Dermatitis by Inducing Eosinophil Infiltration
Effect of chymase inhibitors on ear edema induced by repeated painting with DNFB. Ear edema was induced by repeated painting with DNFB, and ear thickness was measured at 0, 1, 6, 24, and 48 hours after each painting using a thickness gauge. Increase in ear thickness was determined by subtracting the ear thickness before the first painting from that of each point after. Chemicals were administered ip once a day, five times a week. Only the data after the third painting were shown. A, prednisolone; B, SUN-C7512; C, SUN-C8077; D, SUN-C8257. Closed square, vehicle; Open circle, 10 mg/kg; Open triangle, 30 mg/kg (A) or 50 mg/kg (B–D). Data are mean ± sem *, p < 0.05 as compared with the vehicle group (Dunnett's test, n = 6 or 7).
