Figure 2

Spasmolytic polypeptide immunostaining in rat models. a, Group I, physiologic staining in mucous neck cells in midgland zone; b, Group II, scattered spasmolytic polypeptide (SP)–positive staining at base of glands; c, Group III, expansion of midgland zone; d, Group IV, expansion of SP staining to base of glands; e, Group VI, development of spasmolytic polypeptide–expressing metaplasia (SPEM) at base of atrophic mucosa. Left, Bar = 100 μm. Right, Bar = 30 μm.