Table 2 Localization of ST6Gal I and Sialylated Ligands for CD22 and Sialoadhesin in Normal Liver Tissues and Various Liver Lesions

From: Differential Expression of β-Galactoside α2,6 Sialyltransferase and Sialoglycans in Normal and Cirrhotic Liver and Hepatocellular Carcinoma

Tissues

Cases

ST6-G1

CD22Rg

SnRg

Normal liver

6

   

 Hepatocytes

 

G+a

B+

B+

 Bile ducts

 

—

M+

M+

 Kupffer cells

 

—

C+

C+

 Endothelium

 

—

C+

C+

Liver cirrhosis

8

   

 Hepatocytes

 

G+

B+

B+

 Oval cells

 

—

C+

C+

Well and moderately differentiated HCC

6

G+C+

G+C+M+

G+C+M+

Poorly differentiated HCC

4

C+/−

C+/−

C+/−

Cholangiocarcinoma

1

—

C+M+

C+M+

Malignant epitheloid

Hemangioendothelioma

1

—

C+M+

C+M+

  1. B = present along the bile canaliculi; C = present in the diffuse cytoplasm.
  2. Scoring: +, >30% positive cells; +/−, 5–30% positive cells; −, cells not reactive.
  3. aAll cases in each group display similar staining patterns.
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