Figure 8 | Laboratory Investigation

Figure 8

From: Coxsackievirus B3-Associated Myocardial Pathology and Viral Load Reduced by Recombinant Soluble Human Decay-Accelerating Factor in Mice

Figure 8

Cleaved Fc and whole IgG reduce virus replication and myocardial injury. Mice were given either Fc protein cleaved from DAF-Fc, whole human IgG, or PBS (Day 0), infected with CVB3, and killed at Day 7. Heart tissue was submitted for histologic grading, quantitation of in situ hybridization for virus positive-strand RNA, and plaque assay to detect infectious virus particles. Cleaved Fc, and to a greater extent whole IgG, reduced myocarditic cell death and lesion area (A), virus replication (B), and infectious virus particles (C) in the heart.

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