Figure 1 | Laboratory Investigation

Figure 1

From: The Myofibroblastic Conversion of Peribiliary Fibrogenic Cells Distinct from Hepatic Stellate Cells Is Stimulated by Platelet-Derived Growth Factor During Liver Fibrogenesis

Figure 1

Phenotype of fibrogenic cells in early biliary-type liver fibrosis. Liver tissue sections from sham-operated (A, C, and E), and bile duct–ligated (B, D, and F) rats on postoperative Day 2 were submitted to Sirius red staining (A and B), smooth muscle α-actin (α-SMA) (C and D), and desmin (E and F) immunolabeling. Portal tract–centered photomicrographs are shown. In sham-operated rats, collagen staining (A) is detected in low amounts predominantly in portal tracts; α-SMA (C) and desmin (E) (arrowhead) immunoreactivity is restricted to portal vessel walls. In bile duct–ligated rats, proliferative bile ducts are encircled by fibrosis (B) and by α-SMA immunoreactivity (D) restricted to the portal tracts and to rare immediately adjacent sinusoidal cells, whereas desmin immunoreactivity (F) is detected in a large number of sinusoidal cells (open arrowheads) and in only rare periductular cells (closed arrowhead). Original magnifications: A, × 200; B to F, × 400.

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