Figure 8 | Laboratory Investigation

Figure 8

From: The Myofibroblastic Conversion of Peribiliary Fibrogenic Cells Distinct from Hepatic Stellate Cells Is Stimulated by Platelet-Derived Growth Factor During Liver Fibrogenesis

Figure 8

STI571-induced changes in peribiliary α-SMA immunoreactivity in bile duct–ligated rats. Daily ip injections of STI571 (20 mg/kg) or of vehicle were started 1 day before bile duct ligation. α-SMA was detected by an indirect immunoperoxidase method on liver tissue sections from (A) vehicle-treated and (B) STI571-treated bile duct–ligated rats on postoperative Day 2. Although in STI571-treated bile duct–ligated rats the number of bile duct structures was unchanged (open arrowheads), periductular α-SMA immunoreactivity was dramatically decreased. Representative results obtained in five rats in each group are shown. Original magnification, × 400.

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