Table 1 Correlation of the Expression Level of α4GnT mRNA in the Mononuclear Cell Fraction of Peripheral Blood from Patients with Gastric Cancer with Clinicopathological Variables

From: Usefulness of the Real-Time Reverse Transcription-Polymerase Chain Reaction Assay Targeted to α1,4-N-Acetylglucosaminyltransferase for the Detection of Gastric Cancer

 

Frequency of positive patientsa

α4GnT:GAPDH ratiob (mean ± se)

p

Tumor stage

 I

11/19 (57.9%)

1.632 ± 0.492

 

 II

2/6 (33.3%)

4.073 ± 3.548

<0.05c

 III

4/6 (66.7%)

14.389 ± 7.249

 

 IV

6/6 (100%)

16.210 ± 9.614

 

Depth of tumor invasion

 Intramucosa

4/5 (80.0%)

1.090 ± 0.560

 

 Submucosa

6/11 (54.5%)

2.135 ± 0.780

 

 Proper muscle

2/4 (50.0%)

6.345 ± 5.180

0.8301d

 Subserosa

4/8 (50.0%)

9.575 ± 5.760

 

 Serosa

6/8 (75.0%)

13.205 ± 7.525

 

Venous invasion

 Negative

12/18 (66.7)

3.117 ± 1.351

0.7942e

 Positive

10/18 (55.6%)

10.024 ± 4.135

 

Lymphatic invasion

 Negative

7/12 (58.3%)

1.760 ± 0.681

0.3778e

 Positive

15/24 (62.5%)

8.976 ± 3.225

 

Lymph node metastasis

 Negative

11/20 (55.0%)

1.662 ± 0.475

0.0850e

 Positive

11/16 (68.8%)

12.705 ± 4.587

 

Distant metastasis

 Negative

17/31 (54.8%)

4.573 ± 1.729

0.0157e

 Positive

6/6 (100%)

16.211 ± 9.615

 

Histopathologyf

 Intestinal type

15/25 (60.0%)

5.781 ± 1.156

0.3858e

 Diffuse type

8/12 (66.7%)

20.671 ± 5.967

 
  1. aThe amounts of α4GnT mRNA more than 40 copies/ml in a reaction tube are defined as positive.
  2. bα4GnT:GAPDH mRNA ratios multiplied by 1.0 × 107 are indicated.
  3. cAnalyzed by Dunnett's test. Significant difference was found between stage I and IV.
  4. dAnalyzed by Kruskal-Wallis test.
  5. eAnalyzed by Mann-Whitney U test.
  6. fThe Laurén classification.
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