Figure 6

Exogenous treatment with recombinant SCF increases survival (A) and reduced serum liver enzymes in animals treated with a lethal dose of acetaminophen. Animals were treated with 1 μg of recombinant SCF or saline within 30 minutes of acetaminophen administration (300 mg/kg). The survival of animals was recorded for 6 days and the experiment was terminated. Data represent percentage survival from two separate experiments with a total of 20 mice in each treatment group. Liver enzyme levels were examined after 24 hours after acetaminophen treatment (300 mg/kg) with or without SCF treatment (1 μg/mouse intraperitoneally). The data in Figure 6B represent the mean ± se from six to seven mice per group.