Figure 7

Livers from animals given exogenous SCF have no evidence of damage histologically at 4 days after lethal acetaminophen (300 mg/kg) administration. Animals were treated with 1 μg of recombinant SCF or saline within 30 minutes of acetaminophen administration (300 mg/kg). The survival of animals was recorded for 4 days and the experiment was terminated. The livers were examined histologically and demonstrated that animals treated with recombinant SCF had minimal necrotic area (A), whereas large areas of damage could easily be found in saline-treated animals (B).