Table 2 Genes Up-Regulated in LMP1-Expressing NP69 Cells Detected by cDNA Array

From: Alterations of Biologic Properties and Gene Expression in Nasopharyngeal Epithelial Cells by the Epstein-Barr Virus–Encoded Latent Membrane Protein 1

Gene descriptions

Ratio (L/C)a

Putative functions

rho GDP dissociation inhibitor 2 (RhoGD12)

9.91

Commonly expressed in hematopoietic cells. Member of Rho GDI family, maybe for GTPase activity modulator.

Fibronectin 1 (FN1)

9.74

Extracellular matrix protein, for promoting cell adhesion and morphology.

Tyrosine-protein kinase receptor (AXL)

5.21

Oncogene, for regulating cell proliferation and transformation.

Membrane-type MMP-3 (MT–MMP-3 or MMP-16)

5.16

Metalloproteinase, for degrading extracellular matrix.

Vitronectin precursor (VTN)

4.91

Intermediate filament protein, for cell attachment and spreading.

Endothelin 2 (ET2)

4.75

Cytokine, function as vasoconstricting or anti-inflammatory agent.

Vascular endothelial growth factor (VEGF)

4.56

Cytokine, angiogenic factor for inducing cell proliferation and migration.

Neutrophil gelatinase-associated lipocalin (NGAL)

4.36

Associated with neutrophil gelatinase, functions as a modulator of inflammation.

Vimentin (VIM)

4.12

Intermediate filament protein, for cytoskeleton framework of the cells.

GTP-binding protein ras associated with diabetes (RAD)

4.10

Ras-related GTPase, maybe for regulating cytoskeleton.

SL cytokine precursor; FLT3 ligand (FLT3LG)

3.97

Ligand of FLT3 receptor, for stimulating proliferation of hematopoietic progenitor cells.

Transforming growth factor-β2 (TGF-β2)

3.08

Natural and potent growth inhibitors in normal cells but stimulate the invasiveness of tumor cells.

Thrombospondin 2 (THBS2)

2.65

Matrix adhesion receptors, for cell adhesion and migration.

Leukocyte interferon-inducible peptide

2.60

Extracellular matrix protein, for inflammation.

Transforming growth factor-β (TGF-β)

2.58

Natural and potent growth inhibitors in normal cells but stimulate the invasiveness of tumor cells.

NDR protein kinase

2.29

Nuclear kinase, for regulating growth and morphology.

High mobility group protein (HMG-I)

2.12

Chromosomal protein, for regulating transcription, but also secreted for inflammation and tumor metastasis.

  1. aExpression ratio: expression intensity in LMP1-NP69 cells/expression intensity in pLNSX-NP69 cells.
Back to article page