Figure 2 | Laboratory Investigation

Figure 2

From: IL-4 Receptor Signaling Is Required for Mannose Receptor Expression by Macrophages Recruited to Granulomata but not Resident Cells in Mice Infected with Schistosoma mansoni

Figure 2

Expression of MΦ markers in ilea of infected WT and IL4Rα −/− mice. Serial sections of wild-type (WT) and IL4Rα −/− ileum specimens were examined by immunocytochemistry using the antibodies indicated. MΦ, labeled for FA.11, were abundant in granulomata, which formed close to the muscle wall. The arrow in the upper-right image indicates an embolized egg. Mannose receptor (MR) was only detected in the WT granuloma. Boxed regions in the lower magnification images of FA.11 and MR labeling are shown at higher magnification below. Although MΦ were clearly negative for MR in the IL4Rα −/−, lymphatic endothelium, indicated by the arrow, was labeled with the Ab. Lower magnification images of the inflammatory cells labeled with MHCII and F4/80 are also shown. Scale bars are shown for each row of images and are 50 μm.

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