Figure 3 | Laboratory Investigation

Figure 3

From: IL-4 Receptor Signaling Is Required for Mannose Receptor Expression by Macrophages Recruited to Granulomata but not Resident Cells in Mice Infected with Schistosoma mansoni

Figure 3

Expression of MΦ markers in livers of egg-injected wild-type (WT) and IL4Rα −/− mice. Serial sections of WT and IL4Rα −/− liver specimens were examined by immunocytochemistry as indicated. MΦ-rich granulomata, detected with F4/80 Ab, were found around schistosome eggs (indicated by arrowheads). Granuloma MΦ were positive for mannose receptor (MR) labeling only in WT. Granulomata are indicated with broken lines, and higher magnification images of single granulomata are shown. In these, MR-labeled Kupffer cells and hepatic endothelium are indicated with arrowheads and arrows, respectively. Dark pigment is due to positive staining only, as schistosome-derived debris was not found in this model. Granulomata of both WT and IL4Rα −/− were positive for MHCII labeling. Scale bars are shown for each row of images and are 100 μm.

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