Figure 3 | Laboratory Investigation

Figure 3

From: Identification of CARS-ALK Fusion in Primary and Metastatic Lesions of an Inflammatory Myofibroblastic Tumor

Figure 3

Interphase fluorescence in situ hybridization with the LSI ALK Dual Color, Break Apart Rearrangement Probe (Vysis, Inc.). (A) Lung mass resected in 2002 revealing (1) small nucleus with no rearrangement of ALK, (2) oblong nucleus with two normal copies and two balanced rearrangements of ALK, and (3) large horseshoe-like nucleus with multiple normal copies and unbalanced rearrangements of ALK signified by loss of the 5′ centromeric (green signal) and extra copies of the 3′ telomeric (red signal) portions of this gene. (B) Primary tumor resected in 1991 showing unbalanced ALK rearrangements (loss of 5′ and extra copy of 3′ portions) in two large nuclei.

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