Figure 6 | Laboratory Investigation

Figure 6

From: Identification of CARS-ALK Fusion in Primary and Metastatic Lesions of an Inflammatory Myofibroblastic Tumor

Figure 6

Western blot analysis of the recurrent metastatic tumor with a rat polyclonal antibody raised against aminoacids 1359 to 1446 at the C terminus of human ALK. (A) Control neuroblastoma cell line IMR32 shows a single band of approximately 180 kd, corresponding to the full length anaplastic lymphoma kinase (ALK). The inflammatory myofibroblastic lung tumor (from 2002) shows an intense band, approximately 130 kd, indicating the aberrantly sized chimeric protein with the preserved C terminus of ALK. (B) Sample loading control with the α-tubulin antibody.

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