Figure 1 | Laboratory Investigation

Figure 1

From: Renal Damage in the SHR/N-cp Type 2 Diabetes Model: Comparison of an Angiotensin-Converting Enzyme Inhibitor and Endothelin Receptor Blocker

Figure 1

A, Obese diabetic SHR/N-cp rat with marked sclerosis and attachment of the capillary tuft to the Bowman's capsula. Tubuli are dilated with atrophic epithelium, luminal deposition of eosinophilic material. Some additional interstitial fibrosis with scar around cell infiltrates. B, Lean nondiabetic control animal with normal glomerular and tubular structure. C, Glomeruli of ETA-receptor blocker (ETA-RB)-treated diabetic obese SHR/N/-cp animal. Note only minor mesangial matrix expansion. No tubulointerstitial change. D, Glomeruli of angiotensin-converting enzyme inhibitor (ACE-i)-treated diabetic obese SHR/N-cp animal with some hypertrophy of mesangial cells. No tubulointerstitial changes. Original magnification, ×200 (periodic acid-Schiff stain).

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