Figure 3
From: COX-2/VEGF-Dependent Facilitation of Tumor-Associated Angiogenesis and Tumor Growth in vivo
Effects of cyclo-oxygenase (COX) inhibitors on angiogenesis formed around Millipore chambers containing tumor cells. (A) Typical appearance of granulation tissues formed around Millipore chambers containing sarcoma 180 cells. Aspirin or NS-398 suspension in 5% gum Arabic in distilled water was administered (10 mg/kg) orally bid for 5 days. Vehicle mice were given only vehicle solution (5% gum Arabic in distilled water). (B) Hemoglobin content of granulation tissues formed around the Millipore chambers (sarcoma 180 cells). Data (Day 5) are means ± sem for the numbers of chambers indicated in parentheses. *p < 0.05 versus vehicle-treated mice (ANOVA). (C) Typical appearance of granulation tissues formed around Millipore chambers containing Lewis lung carcinoma (LLC) cells. (D) Hemoglobin content of granulation tissues formed around Millipore chambers (LLC cells). Data (Day 5) are means ± sem for the numbers of chambers indicated in parentheses. *p < 0.05 versus vehicle-treated mice (ANOVA).
