Figure 5 | Laboratory Investigation

Figure 5

From: Insights into the Mechanisms of Gastric Adaptation to Aspirin-Induced Injury: A Role for Regenerating Protein but Not Trefoil Peptides

Figure 5

in situ hybridization of RegI in rat gastric epithelium. In normal rat stomach, RegI mRNA is expressed in cells located mainly in the lower half of the epithelium (A). The number of cells in which RegI mRNA is detected is increased at sites of injury 4 hours after aspirin (B). In adapted stomachs, RegI mRNA expression is increased in areas that are essentially microscopically normal (C). Similarly, immunohistochemistry shows normal expression of RegI protein mainly in the lower half of the epithelium (D), with increased expression at sites of injury in unadapted stomach (E). In adapted stomach, RegI protein expression is also increased in undamaged and healing epithelium (F).

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