Figure 6

Onset and offset of adaptation to aspirin. A, Macroscopic gastric epithelial injury after varying daily doses of vehicle or 120 mg/kg aspirin as outlined (n = 5–6 per group). *p < 0.05 compared with the control, adapted, and offset control groups (1, 4, and 6, respectively). RegI during onset and offset of adaptation to aspirin. B, RT-PCR of RegI mRNA in the corresponding treatment groups (as outlined in A) (n = 5–6 per group). *p < 0.05 compared with the control, single-dose, and offset control groups (1, 2, and 6, respectively). C, Northern blot of RegI and rL32 showing n = 2 from the corresponding treatment groups (as above).