Figure 1
From: Cell Death in MMTV-c-myc Transgenic Mouse Mammary Tumors May Not Be Typical Apoptosis
Hematoxylin and eosin (HE) staining of c-myc transgenic mammary tumors. Many dead cell islands appear in the major tumor areas (arrowheads in A and arrows in C), but not in the glandular foci (A) nor the mixed type of foci that contains tumor glands (arrow in B). However, there may be some dead tumor cells (arrowheads in A and arrows in D) in the tumor glands that resemble necrosis. At early stage of dead cell island formation, a group of tumor cells (arrow in E) are separate from their surrounding tumor cells by an intercellular space that might have resulted from cell shrinkage; at this time point, the morphology of these cells is still similar to the surrounding cells. Cells in dead cell islands show nuclear fragmentation (arrow in F and G), nuclear condensation (arrowhead in G) or peripheral chromatin condensation (arrow in H). There are many small nuclear fragment-like components inside one giant cell (arrowhead in F), which may be a macrophage. Cell debris appears in a dead cell island (arrow in I).
