Table 1 Clonality and HPV Infection of CIN

From: Monoclonal Expansion with Integration of High-Risk Type Human Papillomaviruses Is an Initial Step for Cervical Carcinogenesis: Association of Clonal Status and Human Papillomavirus Infection with Clinical Outcome in Cervical Intraepithelial Neoplasia

Case

Months

Histologic examination

Clonality

HPV type

HPV-16 physical status

Progressed

     

1

0

CIN1

Poly

16

Episomal

 

24

CIN3

Mono A

16

Mixed

2

0

CIN1

Mono B

18

NI

 

15

CIN3

Mono B

18

NI

3

0

CIN1

Mono B

52

NI

 

8

CIN2

Mono B

52

NI

4

0

CIN1

Mono B

52

NI

 

7

CIN3

Mono B

52

NI

5

0

CIN1

Mono A

16

Mixed

 

18

CIN3

Mono A

16

Mixed

6

0

CIN2

Mono A

16

Mixed

 

30

CIN3

Mono A

16

Mixed

7

0

CIN2

Mono B

16

Mixed

 

14

CIN3

Mono B

16

Mixed

8

0

CIN2

Mono B

16

Mixed

 

20

CIN3

Mono B

16

Mixed

9

0

CIN2

Mono B

+

NI

 

9

CIN3

Mono B

+

NI

10

0

CIN2

Mono A

11, 16

Mixed

 

20

CIN3

Mono A

11, 16

Mixed

Persistent

     

11

0

CIN1

Mono A

16

Mixed

 

39

CIN1

Poly

52

NI

12

0

CIN1

Poly

16

Episomal

 

32

CIN1

Poly

16

Episomal

13

0

CIN1

Mono B

−

NI

 

9

CIN1

Mono A

−

NI

 

22

CIN1

Poly

−

NI

14

0

CIN1

Mono A

31

NI

 

27

CIN1

Mono A

31

NI

15

0

CIN1

Poly

−

NI

 

9

CIN1

Poly

−

NI

16

0

CIN1

Not informative

−

NI

 

16

CIN1

Not informative

−

NI

17

0

CIN1

Mono B

58

NI

 

11

CIN1

Mono B

58

NI

18

0

CIN1

Mono B

58

NI

 

22

CIN1

Mono B

58

NI

 

25

CIN1

Mono A

−

NI

 

36

CIN1

Mono A

−

NI

19

0

CIN1

Poly

16

Mixed

 

20

CIN1

Poly

16

Mixed

 

29

CIN1

Mono A

16

Mixed

20

0

CIN1

Mono A

11, 16

Mixed

 

8

CIN1

Mono A

11, 16

Mixed

21

0

CIN2

Mono A

16

Mixed

 

15

CIN2

Mono A

16

Mixed

22

0

CIN2

Mono B

16, 52

Mixed

 

18

CIN2

Mono B

16, 52

Mixed

23

0

CIN2

Mono A

−

NI

 

47

CIN2

Mono A

−

NI

24

0

CIN2

Mono B

16, 52

Mixed

 

30

CIN2

Mono B

16, 52

Mixed

25

0

CIN2

Mono A

11, 33

NI

 

13

CIN2

Mono A

11, 33

NI

regressed

     

26

0

CIN1

Poly

16

Episomal

 

30

No abnormal cytology

   

27

0

CIN1

Mono A

16

Mixed

 

35

No abnormal cytology

   

28

0

CIN1

Poly

11

NI

 

41

No abnormal cytology

   

29

0

CIN1

Mono B

−

NI

 

30

No abnormal cytology

   

30

0

CIN1

Poly

11

NI

 

29

No abnormal cytology

   

31

0

CIN2

Not informative

−

NI

 

42

No abnormal cytology

   

32

0

CIN2

Mono A

−

NI

 

41

No abnormal cytology

   

33

0

CIN2

Poly

−

NI

 

30

No abnormal cytology

   

34

0

CIN2

Poly

−

NI

 

30

No abnormal cytology

   

35

0

CIN2

Mono A

16

Mixed

 

17

No abnormal cytology

   

36

0

CIN2

Not informative

+

NI

 

16

No abnormal cytology

   

37

0

CIN2

Poly

58

NI

 

20

No abnormal cytology

   

38

0

CIN2

Poly

16

Mixed

 

15

No abnormal cytology

   
  1. Months, months after initial diagnosis; Mono A, monoclonal with allele of lower-molecular-weight inactivation; Mono B, monoclonal with allele of higher-molecular-weight inactivation; Poly, polyclonal; +, positive for high-risk HPV but type not determined; −, HPV not detected; Episomal, episomal form; Mixed, mixed type of episomal form and integrated form; NI, not informative for HPV 16 physical status (HPV positive but not type 16).
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