Table 1 Summary of Susceptible Loci Influencing Amyloidosis In (A/J × P1)F₂ Mice

Locus	Position	LRS^a	Effect^b	AI^c (A)	AI (H)	AI (P)
D2Mit295	17 cM	8	Additive ↑	2.16 (n = 18)	1.67 (n = 21)	1.48 (n = 15)
D2Mit133	66.8 cM	11	Recessive ↑	2.53 (n = 8)	1.73 (n = 25)	1.55 (n = 21)
D2Mit309	71 cM	7.5	Recessive ↑	2.38 (n = 9)	1.63 (n = 35)	1.74 (n = 10)
D2Mit257	75 cM	10.3	Recessive ↑	2.53 (n = 8)	1.64 (n = 24)	1.66 (n = 22)
D2Mit258	78 cM	10.3	Recessive ↑	2.53 (n = 8)	1.64 (n = 24)	1.66 (n = 22)
D2Mit227	98 cM	4	Recessive ↑	2.20 (n = 10)	1.67 (n = 35)	1.71 (n = 9)
D4Mit89	18.9 cM	6.7	Additive ↓	1.30 (n = 10)	1.77 (n = 24)	2.03 (n = 20)
D4Mit32	69.8 cM	16.4	Dominant ↓	1.37 (n = 7)	1.59 (n = 33)	2.41 (n = 14)
D4Mit13	71 cM	22.6	Dominant ↓	1.48 (n = 8)	1.55 (n = 33)	2.55 (n = 13)
D4Mit160	76 cM	26.6	Dominant ↓	1.48 (n = 8)	1.54 (n = 34)	2.65 (n = 12)
D4Mit129	76.6 cM	27.6	Dominant ↓	1.70 (n = 10)	1.48 (n = 32)	2.65 (n = 12)
D4Mit33	79 cM	31.3	Dominant ↓	1.77 (n = 13)	1.41 (n = 29)	2.67 (n = 12)
D5Mit80	26 cM	4.1	Additive ↓	1.55 (n = 15)	1.76 (n = 19)	2.11 (n = 17)
D19Mit69	6 cM	4.9	Additive ↓	1.51 (n = 14)	1.73 (n = 26)	2.15 (n = 12)
D19Mit16	15 cM	4	Additive ↓	1.57 (n = 15)	1.79 (n = 27)	2.01 (n = 11)
D19Mit67	43 cM	11.5	Additive ↓	1.18 (n = 8)	1.73 (n = 32)	2.23 (n = 14)
D19Mit2	51 cM	7.3	Recessive ↓	1.50 (n = 10)	1.64 (n = 28)	2.19 (n = 16)

^aWhen significant association was detected with more than two models at the same locus, the highest LRS was adopted.
^bEffect of A/J allele on amyloidosis, either decelerative (↓) or accelerative (↑).
^cAI represents mean value of the amyloid index of parent-derived alleles at the various loci. Fifty-four mice from (A/J × SAMP1)F₂ hybrid progenies were used. A designates the A/J-derived allele, H designates the heterozygous allele from SAMP1 and A/J, and P designates the SAMP1-derived allele.

Search