Figure 2 | Laboratory Investigation

Figure 2

From: Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis

Figure 2

Procollagen I mRNA expression in carbon tetrachloride (CCl4)-treated (A, B) and bile duct ligated (C, D) rats. CCl4-treated liver sections show high expression of procollagen I mRNA in areas of fibrosis and in hepatic stellate cells (A); procollagen I mRNA expression is radiating from the central vein and is largely confined to hepatic stellate cells (B, dark field microscopy). In bile duct ligated liver section, high levels of procollagen I mRNA expression are seen around the portal spaces close to bile ducts (C, D), but some labeling of hepatic stellate cells is also observed (C). A × 130; B and D, × 65; C, × 30.

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