Figure 4 | Laboratory Investigation

Figure 4

From: Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis

Figure 4

Cellular retinol-binding protein-1 (CRBP-1) expression in human normal liver (A) and in steatosis (B). In normal liver (A), immunostaining with the antibody against CRBP-1 detects a very low expression in hepatocytes. In contrast, it allows perfect highlighting of hepatic stellate cells clearly located beneath the endothelial cells; delicate cytoplasmic processes along sinusoids and sometimes between hepatocytes are very finely underlined by the CRBP-1 immunostaining. In steatosis (B), the hepatic stellate cell bodies show numerous CRBP-1–negative lipid droplets inside their cytoplasm; delicate cytoplasmic processes positive for CRBP-1 are visible between steatotic enlarged hepatocytes and along sinusoids.

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