Figure 2
From: Specific MAP-Kinase Blockade Protects against Renal Damage in Homozygous TGR(mRen2)27 Rats
Immunostaining and morphometric analysis for α-smooth muscle actin (SMA) in the renal interstitium. SMA score was higher in untreated Ren2 rats than in untreated sd rats, and significantly lower in Ren2 rats receiving an angiotensin II type 1 receptor antagonist (AT1-RA), extracellular signal-regulated kinase (ERK) inhibitor, or p38 inhibitor, when compared with untreated Ren2 rats (diagram). Figures represent immunohistochemistry for SMA in the interstitium of untreated sd rats (A), and Ren2 rats (B: untreated, C: AT1-RA, D: ERK inhibitor). Results for the group that received a p38 inhibitor were comparable to D. Original magnification: × 200. *p < 0.05 vs untreated sd rats. **p < 0.05 vs untreated Ren2 rats.
