Figure 3
From: Specific MAP-Kinase Blockade Protects against Renal Damage in Homozygous TGR(mRen2)27 Rats
Desmin expression, indicating damage to the glomerular epithelium (podocytes), was increased in untreated Ren2 rats. Treatment with an angiotensin II type 1 receptor antagonist (AT1-RA), as well as an extracellular signal-regulated kinase (ERK) or p38 inhibitor significantly reduced desmin scores. Figures represent glomeruli of sd (A) and Ren2 rats, either untreated (B), or treated with an AT1-RA (C) or p38 inhibitor (D). Results for the group that was treated with an ERK inhibitor were comparable to D. Original magnification: × 350. *p < 0.05 vs sd. **p < 0.05 vs Ren2.
