Figure 4
From: Specific MAP-Kinase Blockade Protects against Renal Damage in Homozygous TGR(mRen2)27 Rats
Mesangial matrix expansion (MME) was increased in the untreated Ren2 group. The angiotensin II type 1 receptor antagonist (AT1-RA) and p38 inhibitor, but not the extracellular signal-regulated kinase (ERK) inhibitor, significantly reduced MME. Representative images after periodic acid-Schiff staining, demonstrating the extent of MME. (A) Untreated sd rats, (B) Untreated Ren2 rats, (C) Ren2 rats treated with AT1-RA, (D) Ren2 rats treated with p38 inhibitor. Original magnification: × 350. *p < 0.05 vs sd. **p < 0.05 vs Ren2.
