Figure 4

Immunohistochemical expression of adipocyte-derived leucine aminopeptidase (A, C, and E) and placental leucine aminopeptidase (B, D, and F) in placental site trophoblastic tumor (PSTT) tissues. (A and B) Uterine lesions of PSTT showing focally positive PSTT cells (arrowheads). (C and D) Lesions of scattered invasion into myometrium and stromal vessels (V). (E and F) Lung metastasis lesions showing invasion into alveolar (Alv) tissues and adjacent vessels. Both aminopeptidases were strongly expressed in invading PSTT cells. Original magnifications: × 400 (A and B), × 100 (C to F).