Table 2 Expression of SHP1 Protein and CpG Island Methylation of the SHP1 Gene in Malignant Lymphomas

From: Activated Proliferation of B-Cell Lymphomas/Leukemias with the SHP1 Gene Silencing by Aberrant CpG Methylation

Diagnosis

Subtype

SHP1 proteina (%)

SHP1 gene methylationb (%)

  

++

+

−

 

DLBCL

Nodal

1/12c (8.3)

0/12 (0)

11/12 (91.7)

23/26 (88.5)

 

Extranodal

0/12 (0)

0/12 (0)

12/12 (100)

19/19 (100)

 

Total

1/24 (4.2)

0/24 (0)

23/24 (95.8)

42/45 (93.3)

MALT lymphoma

Low grade

3/26 (11.5)

9/26 (34.6)

14/26 (53.9)

7/10 (70)

 

High graded

0/10 (0)

2/10 (20)

8/10 (80)

7/7 (100)

 

Total

3/36 (8.3)

11/36 (30.6)

22/36 (61.1)

14/17 (82.4)

MCL

 

1/13 (7.7)

0/13 (0)

12/13 (92.3)

3/4 (75)

Plasmacytoma

 

0/17 (0)

0/17 (0)

17/17 (100)

5/5 (100)

FL

Grade 1

0/6 (0)

0/6 (0)

6/6 (100)

11/11 (100)

 

Grade 2

0/6 (0)

0/6 (0)

6/6 (100)

9/10 (90)

 

Grade 3

0/2 (0)

0/2 (0)

2/2 (100)

3/3 (100)

 

Total

0/14 (0)

0/14 (0)

14/14 (100)

23/24 (95.8)

PBMCs

Healthy donor

11/11 (100)

0/11 (0)

0/11 (0)

0/11 (0)

RLH

Germinal center

0/10 (0)

0/10 (0)

10/10 (100)

n.d.

 

Mantle zone

10/10 (100)

0/10 (0)

0/10 (0)

n.d.

 

Interfollicular

6/10 (60)

4/10 (40)

0/10 (0)

n.d.

  1. DLBCL, diffuse large B-cell lymphoma; MALT lymphoma, marginal zone lymphoma MALT type; MCL, mantle cell lymphoma; FL, follicular lymphoma; PBMCs, peripheral blood mononuclear cells; RLH, reactive lymphoid hyperplasia; n.d., not done.
  2. aDetected by immunohistochemical staining with tissue microarray and standard immunohistochemistry.
  3. bDetected by methylation-specific PCR.
  4. cThe number of expression-positive or methylation-positive samples/the number of total samples.
  5. DLBCL with MALT lymphoma.
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