Table 2 Probability of finding residual tumor in the re-excision specimen as a function of patient age, margin status, mammographic appearance, tumor size, nuclear grade, presence of necrosis and histological microcalcifications
From: Histological margin assessment for breast ductal carcinoma in situ: precision and implications
Variable | Residual tumor | (%) | P-valuea |
|---|---|---|---|
Age (years) | |||
<45 | 8/16 | (50) | 0.2NS |
≥45 | 51/73 | (70) | |
Margin status | |||
Close >1 mm width | 4/9 | (44) | 0.006 |
Close ≤1 mm width | 10/22 | (45) | |
Positive <1 mm focal involvement | 6/9 | (67) | |
Positive ≥1<15 mm minimal involvement | 22/31 | (71) | |
Positive ≥15 mm extensive involvement | 17/18 | (94) | |
Mammographic appearance | 0.8NS | ||
Microcalcifications | 48/74 | (65) | |
Microcalcifications with mass | 6/8 | (75) | |
Mass | 5/7 | (71) | |
Mammographic tumor size (mm)b | 0.2NS | ||
0–10 | 16/26 | (62) | |
11–25 | 22/36 | (61) | |
>25 | 15/18 | (83) | |
Pathologic tumor size (mm)c | 0.02 | ||
0–10 | 3/11 | (27) | |
11–25 | 19/28 | (68) | |
>25 | 28/38 | (74) | |
Nuclear grade | 0.9NS | ||
Low | 7/11 | (64) | |
Intermediate | 27/42 | (64) | |
High | 25/36 | (69) | |
Intraductal necrosis | 0.6NS | ||
Absent | 7/14 | (50) | |
Scant | 18/27 | (67) | |
Moderate/extensive | 33/48 | (69) | |
Histological microcalcificationsb | |||
Present | 51/79 | (65) | 0.7NS |
Absent | 7/9 | (78) |
