Figure 14
From: Diagnosis and reporting of limited adenocarcinoma of the prostate on needle biopsy
(a) Small focus of atypical glands, highly suspicious for adenocarcinoma of the prostate. (b) Stains for high molecular weight cytokeratin are negative in atypical glands, consistent with adenocarcinoma. (c) Stains for AMACR are intensely positive in the atypical glands, also consistent with adenocarcinoma. Note (lower right) a benign-appearing gland with some AMACR positivity. It is not uncommon adjacent to adenocarcinomas to have benign appearing glands that are focally positive for AMACR. These may represent early pre-neoplastic changes that are not evident morphologically.
