Table 4 Relationship between CD117 and bio-pathological variables in 113 squamous cell carcinoma patients
Variable | Category | Membrane | P | Cytoplasmic | P | ||
|---|---|---|---|---|---|---|---|
0–4.99% | ≥5% | 0–4.99% | ≥5% | ||||
Age (year) | Median | 63 | 64 | NS | 63 | 66 | NS |
Gender | Male | 95 (97%) | 14 (93%) | NS | 101 (96%) | 8 (100%) | NS |
Female | 3 (3%) | 1 (7%) | 4 (4%) | 0 | |||
Symptoms at diagnosisa | Absent | 27 (28%) | 8 (53%) | NS | 33 (32%) | 2 (25%) | NS |
Local | 41 (43%) | 5 (33%) | 43 (42%) | 3 (37%) | |||
Systemic | 27 (28%) | 2 (13%) | 26 (26%) | 3 (37%) | |||
Vascular invasion | Yes | 71 (72%) | 13 (87%) | NS | 77 (73%) | 7 (87%) | NS |
No | 27 (28%) | 2 (13%) | 28 (27%) | 1 (13%) | |||
pT | 1 | 52 (53%) | 5 (33%) | NS | 53 (50%) | 4 (50%) | NS |
2 | 46 (47%) | 10 (67%) | 52 (49%) | 4 (50%) | |||
Tumor grade | 1 | 1 (1%) | 0 | 0.001 | 1 (1%) | 0 | 0.03 |
2 | 71 (72%) | 4 (27%) | 73 (70%) | 2 (25%) | |||
3 | 26 (27%) | 11 (73%) | 31 (29%) | 6 (75%) | |||
Size (cm) | Median | 3.0 | 4.0 | NS | 3.0 | 3.3 | NS |
Ki-67 (%) | Median | 42 | 37 | NS | 42 | 32.5 | NS |
Synaptophysin | Neg | 89 (91%) | 12 (80%) | NS | 94 (90%) | 7 (87%) | NS |
Pos | 9 (9%) | 3 (20%) | 11 (10%) | 1 (12%) | |||
Chromogranin A | Neg | 89 (91%) | 14 (93%) | NS | 95 (90%) | 8 (100%) | NS |
Pos | 9 (9%) | 1 (7%) | 10 (9%) | 0 | |||
Fascin | Neg | 0 | 2 (13%) | 0.009 | 1 (1%) | 1 (12%) | NS |
Pos | 98 (100) | 13 (87%) | 104 (99%) | 7 (87%) | |||
Her-2 | Neg | 65 (66%) | 7 (47%) | NS | 67 (64%) | 5 (62%) | NS |
Pos | 33 (34%) | 8 (53%) | 38 (34%) | 3 (37%) | |||
Bcl-2 (%) | Median | 1.9 | 78.5 | <0.001 | 3.0 | 3.3 | NS |
Cyclin-E (%) | Median | 29.8 | 17.3 | NS | 2.2 | 30.5 | 0.007 |
p53 (%) | Median | 6.0 | 24.0 | NS | 31.0 | 0 | NS |
p21Waf1(%) | Median | 14.5 | 10.8 | NS | 14.3 | 11.5 | NS |
p27Kip1 (%) | Median | 9.3 | 41.4 | 0.001 | 10.4 | 26.2 | NS |
Microvessel density | Median | 90 | 108 | 0.04 | 92 | 94 | NS |
