Figure 2
Ploidy studies by FISH, using differentially labeled probes, showing XX diploidy and trisomy 11. Studies were performed on 5 μm sections (c) or intact interphase nuclei (a,b,d). (a) Cells show two X chromosome signals and no Y chromosome signals consistent with an XX gestation. (b) Villous cells show two signals for both chromosomes 8 and 18 consistent with diploidy. (c) Cells show three signals for probe spanning the CDKN1C locus on chromosome 11p. (d) Cells also show three signals for chromome 11q and centromeric probes.
