Table 2 Association of 14-3-3σ CpG island methylation (by methyaltion-specific PCR) and protein expression in 66 tumors from the urological and gynecological tracts

From: Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

 

Methylation-specific PCR

 

−

(+)

+

++

 

M (methylated)

     

 IHC-positive (n=32)a

2

15

14

1

 

 IHC-negative (n=34)b

0

6

19

9

P=0.003*

U (unmethylated)

     

 IHC-positive (n=32)

1

13

14

4

P=0.006**

 IHC-negative (n=34)

9

16

9

0

 
  1. Association between IHC-negativity and methylation signal (M)* and IHC-positivity and unmethylation signal (U)**.
  2. a IHC-positive cases (ovarian (n=7), prostate (n=15), endometrial (n=10)).
  3. b IHC-negative (ovarian (n=10), prostate (n=15) and endometrial (n=9)).
Back to article page