Table 3 D2-40, calretinin, WT1, and cytokeratin 5/6 staining characteristics in selected tumors

From: Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma

 

n

D2-40 positive (%)

Calretinin positive (%)

WT1 positive (%)

CK 5/6 positive (%)

Mesothelioma, all subtypes

53

51 (96)

51 (96)

29 (55)

43 (83)a

 Epithelioid

33

33 (100)

33 (100)

19 (58)

29 (91)a

 Biphasic

16

15 (94)

16 (100)

10 (63)

13 (81)

 Sarcomatoid

4

3 (75)

2 (50)

0 (0)

1 (25)

Pulmonary adenocarcinoma

31

2 (7)

7 (23)

2 (7)

12 (39)

Ovarian serous carcinoma

26

17 (65)b

8 (31)

23 (89)

9 (35)

Renal cell carcinoma, all subtypes

35

5 (14)

4 (11)

1 (3)

13 (37)

 Conventional

16

0 (0)

2 (13)

0 (0)

5 (31)

 Papillary

13

5 (39)c

1 (8)

1 (8)

7 (54)

 Chromophobe

6

0 (0)

1 (17)

1 (17)

1 (17)

  1. aOne case of epithelioid mesothelioma was unavailable for cytokeratin 5/6 staining.
  2. bAll D2-40-positive ovarian serous carcinomas demonstrated a membranous staining pattern.
  3. cAll D2-40-positive papillary renal cell carcinomas demonstrated a cytoplasmic staining pattern.
Back to article page